09/30/2006 - National Legal News

A new study published in the medical journal Neuropsychopharmacology reveals that the popular acne drug may have a biological link to an increase in depressed behavior among users.

The research, completed jointly by scientists from the University of Texas at Austin and the University of Bath in England, gives experts another look into the complicated reactions caused by isotretinoin, sold under the brand name Accutane. During the study, mice were administered 13-cis-retinoic acid, which is the active ingredient in isotretinoin. Scientists found that these mice behaved differently than normal mice, making very little attempt to escape stressful situations.

These results strengthen an emerging theory that retinoids, a group of substances to which 13-cis-retinoic acid belongs, can affect the adult human brain in negative ways. Many experts have long thought that Accutane could be linked to depression and suicidal behavior, due to reports of such behavior among otherwise healthy Accutane users.

Researchers involved in the most recent study stress that the behavior of the mice in the study does not necessarily mean that humans are affected in the same way. Much more research is needed to ascertain whether a strong link exists between Accutane and depression.

If you are currently taking Accutane or its generic form, isotretinoin, and are concerned about the possible side effects, talk to your doctor to determine whether the benefits outweigh the risks.